刘海洋（中国科学院昆明植物研究所研究员）

2023-10-22 阅读 1026 评论 0

摘要：刘海洋，男，博士，博士生导师，现任中国科学院昆明植物研究所研究员。研究方向为药物化学、药用植物资源学。刘海洋中国科学院昆明植物研究所博士科研工作者中国科学院昆明植物研究所研究员人物经历教育经历1998-09--2005-01 中国科学院昆明植物研究所博士学位1990-09--1994-07

刘海洋，男，博士，博士生导师，现任中国科学院昆明植物研究所研究员。

研究方向为药物化学、药用植物资源学。

刘海洋

中国科学院昆明植物研究所

博士

科研工作者

中国科学院昆明植物研究所研究员

人物经历

教育经历

1998-09--2005-01 中国科学院昆明植物研究所博士学位

1990-09--1994-07 四川大学（原成都科技大学）学士学位

工作经历

2014.01-至今: 中国科学院昆明植物研究所工作，研究员/课题组长

2014.03-2014.06: 美国密西西比大学高级访问学者

2008.01-2013.12: 中国科学院昆明植物研究所工作，副研究员/课题组长

2005.02-2007.12: 中国科学院昆明植物研究所工作，助理研究员

主要成就

科研成就

1. Xu-Jie Qin#, Tyler J. Rauwolf#, Pan-Pan Li#, Hui Liu, James McNeely, Yan Hua, Hai-Yang Liu*, John A. Porco, Jr.*. Isolation and Synthesis of Novel Meroterpenoids from Rhodomyrtus tomentosa: Investigations of a Reactive Enetrione Intermediate. Angew. Chem. Int. Edit. 2019, 58: 4291-4296.

2. Xu-Jie Qin#, Mi-Yan Feng#, Hui Liu, Wei Ni, Tyler Rauwolf, John A. Porco, Jr., Huan Yan, Li He, Hai-Yang Liu*. Eucalyptusdimers A−C, Dimeric Phloroglucinol−Phellandrene Meroterpenoids from Eucalyptus robusta. Org. Lett. 2018, 20: 5066-5070.

3. Qing Zhao, Jie-Jie Gao, Xu-Jie Qin, Xiao-Jiang Hao*, Hong-Ping He*, and Hai-Yang Liu*. Hedychins A and B, 6,7-Dinorlabdane Diterpenoids with a Peroxide Bridge from Hedychium forrestii. Org. Lett. 2018, 20: 704-707.

4. Zhi Dai#, Hui Liu#, Bei Wang#, Dong Yang#, Yan-Yan Zhu, Huan Yan, Pei-Feng Zhu, Ya-Ping Liu, Hui-Cheng Chen, Yun-Li Zhao, Li-Xing Zhao, Xu-Dong Zhao*, Hai-Yang Liu*, Xiao-Dong Luo*. Structures/Cytotoxicity/Selectivity Relationship of Natural Steroidal Saponins against GSCs and Primary Mechanism of Tribulosaponin A. Eur. J. Med. Chem. 2021, 210, 1113068.

5. Hui Liu#, Xiao-Zhi He#, Mi-Yan Feng#, Yuan-Zeng, Tyler J. Rauwolf, Li-Dong Shao, Wei Ni, Hui Yan, John A. Porco Jr., Xiao-Jiang Hao, Xu-Jie Qin*, Hai-Yang Liu*. Acylphloroglucinols with acetylcholinesterase inhibitory effects from the fruits of Eucalyptus robusta. Bioorganic Chemistry 2020, 103, 104127.

6. Xu-Jie Qin#, Lan-Jun Zhang#, Yu Zhang, Wei Ni, Xing-Zhi Yang, Qian Yu, Huan Yan, Lin-Kun An, Hai-Yang Liu*. Polyphyllosides A‒F, six new spirostanol saponins from the stems and leaves of Paris polyphylla var. chinensis. Bioorganic Chemistry 2020, 99, 103788.

7. Dan Li#, Hui Liu#, Wei Ni, Wei-Lie Xiao, Li He, Zhen-Yu Guo, Xu-Jie Qin*, Hai-Yang Liu*. Molecular networking-based strategy for the discovery of polyacetylated 18-norspirostanol saponins from Trillium tschonoskii Maxim. Phytochemistry 2019, 168, 112125.

8. Huan Yan, Xu-Jie Qin, Xu-Hong Li, Qian Yu, Wei Ni, Li He, Hai-Yang Liu*. Japonicones A-C: three lindenane sesquiterpenoid dimers with a 12-membered ring core from Chloranthus japonicas. Tetrahedron Lett. 2019, 60: 713-717.

9. Xu-Jie Qin,# Ling-Yu Jin,# Qian Yu,# Hui Liu, Afsar Khan, Huan Yan, Xiao-Jiang Hao, Lin-Kun An,* Hai-Yang Liu*. Eucalypglobulusals A–J, Formyl-Phloroglucinol–Terpene Meroterpenoids from Eucalyptus globulus Fruits. J. Nat. Prod. 2018, 81: 2638-2646.

10. Xu-Jie Qin#, Wei Ni#, Chang-Xiang Chen, Hai-Yang Liu*. Seeing the Light: Shifting from Wild Rhizomes to Extraction of Active Ingredients from Above-ground Parts of Paris polyphylla var. yunnanensis. Journal of Ethnopharmacology 2018, 224: 134-139.

11. Hui Liu, Mi-Yan Feng, Qian Yu, Huan Yan, Yuan Zeng, Xu-Jie Qin, Li He, Hai-Yang Liu*. Formyl phloroglucinol meroterpenoids from Eucalyptus tereticornis and their bioactivities. Tetrahedron 2018, 74: 1540-1545.

12. Xu-Jie Qin#, Qian Yu#, Huan Yan, Afsar Khan, Mi-Yan Feng, Pan-Pan Li, Xiao-Jiang Hao, Lin-Kun An*, Hai-Yang Liu*. Meroterpenoids with Antitumor Activities from Guava (Psidium guajava). J. Agric. Food Chem. 2017, 65 (24): 4993–4999.

13. Xu-Jie Qin#, Yong-Ai Si#, Yu Chen#, Hui Liu, Wei Ni , Huan Yan, Yun-Heng Ji, Hai-Yang Liu*. Cytotoxic steroidal saponins from Trillium kamtschaticum. Bioorganic & Medicinal Chemistry Letters 2017, 27： 2267-2273.

14. Ting-Xiang Lu#, Tong Shu#, Xu-Jie Qin, Wei Ni, Yun-Heng Ji, Qi-Run Chen, Qing Zhao, Hai-Yang Liu*. Spirostanol saponins from Ypsilandra parviflora induce platelet aggregation. Steroids 2017, 123: 55-60.

15. Yu Chen, Wei Ni, Huan Yan, Xu-Jie Qin, Afsar Khan, Hui Liu, Tong Shu, Ling-Yu Jin, Hai-Yang Liu*. Spirostanol glycosides with hemostatic and antimicrobial activities from Trillium kamtschaticum. Phytochemistry 2016, 131: 165-173.

16. Xu-Jie Qin, Mu-Yuan Yu, Wei Ni, Huan Yan, Chang-Xiang Chen, Yung-Chi Cheng, Li He, Hai-Yang Liu*. Steroidal Saponins from Stems and Leaves of Paris polyphylla var. yunnanensis. Phytochemistry 2016, 121:20-29.